May 13, 2020
Date: May 13, 2020
Duration: 20 Min
Sponsored by Bio-Rad Laboratories
This webcast features: William H. Rushton, Process Chromatography Support Scientist, Bio-Rad Laboratories
Viral clearance studies are part of a multifaceted approach to ensure the safety of biopharmaceutical products. In order to prevent costly changes to a manufacturing process, it is important to assess each operation unit for its efficiency on the removal or inactivation of adventitious agents early on during downstream process development.
A design of experiments (DOE) approach was utilized in this case study to investigate the effect of buffer pH and conductivity on the removal of various product- and process-related impurities by an anion-exchange (AEX) mixed-mode chromatography resin. Results from these studies have offered insights on the interactions between the resin and minute virus of mice (MVM) and xenotropic murine leukemia virus (XMuLV). A ceramic hydroxyapatite medium and a high-resolution cation-exchange (CEX) resin were also evaluated under typical conditions and will be presented in this webcast.
Overview:
Understand the interaction(s) between a model virus and chromatography resins
Evaluate the effect of critical process parameters
Assess the design space and optimal process condition
Use a pragmatic strategy to ensure viral safety in downstream processing
Watch the recorded webcast now.
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