Big Impact From Small Samples: Harnessing High-Precision Tunable Laser Spectroscopy for Complex Bioprocessing AnalysisBig Impact From Small Samples: Harnessing High-Precision Tunable Laser Spectroscopy for Complex Bioprocessing Analysis

BPI Contributor

January 21, 2025

15 Min View
Nirrin Technologies BPI Ask the Expert webinar

Date: Jan 21, 2025

Duration: 15 Min

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This webcast features: Larissa Miropolsky, senior director of data science, Nirrin Technologies.

The Atlas platform by Nirrin Technologies represents a quantum leap for bioprocessing analytics, harnessing High-Precision Tunable Laser Spectroscopy (HPTLS) to address the most challenging analytical needs. With HPTLS, every scan is calibrated in power and wavelength, achieving such superior signal-to-noise ratios (SNR) that low-level measurements of critical components (like surfactants in complex protein formulations) are now possible from a single, 15 microliter drop with no sample preparation or dilution.

Unlike traditional spectroscopic techniques, Atlas with HPTLS employs an Iterative Optimization Technology (IOT) framework, which simplifies data analysis and interpretation by directly integrating reference library components and well characterized noise sources. This robustness eliminates the need for complex, time-consuming Partial Least Squares (PLS) modeling, making it a powerful tool for bioprocessing workflows.

Key Takeaways:

  • Superior Precision: HPTLS achieves unmatched SNR for low-level measurements in complex matrices.

  • Simplified Modeling: Robust performance and IOT reduce reliance on complex PLS models.

  • Versatile Applications: Successfully quantifies surfactants and other excipients in challenging protein solutions.

  • Impactful Insights: A transformative tool for bioprocessing, optimizing accuracy and efficiency.

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