Author Archives: David Solbach

Reacting to a Pandemic: Innovations in Vaccine Development

Vaccine research, development, and production are multifaceted endeavors. The industry faces a constant need for new methods to increase speed, yield, and product stability — and to produce new vaccines cost-effectively to ensure a stable supply chain. Long before the COVID-19 pandemic, other viral infections such as influenza and rabies already challenged the world and caused millions of deaths (1). Since the 18th century, vaccination has proven to be the most (and in many cases, the only) successful route to…

Production of Transient Lentiviral Vectors in HEK 293T Cells: Cultivation on Fibra-Cel Disks in a Single-Use, Packed-Bed, Stirred-Tank Bioreactor

Although demand for lentiviral vectors (LVs) for cell and gene therapy is increasing, the standard two-dimensional culture systems used to produce LVs present significant disadvantages. Current bottlenecks in LV production are caused mainly by such disadvantages. Switching to use of bioreactors can eliminate those problems because bioreactors offer the benefits of process automation, tight regulation of production conditions, and reduced labor input. The study reported herein was carried out by the group of David Parsons at the University of Adelaide.…