The Effect of Conductivity on Dynamic Binding Capacity on CEX Resins
BPI Contributor
November 12, 2010
1 Min Read
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In an effort to improve the antibody manufacturing platform, newer Cation Exchange Resins were evaluated. Dynamic binding studies were conducted using 2 different monoclonal antibodies at a stable pH and varying conductivities across nine resins to determine the differences in binding capacity. DBC Studies were performed at a pH of 5 and conductivities of 5, 10 and 15 mS/cm for the nine cation exchange resins with breakthrough criteria set at 10%. While most of the resins provided excellent binding capacity (>50 g/L), the impact of conductivity on the dynamic binding capacity was shown to be very molecule dependent and varied significantly with the resin type.
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