Chimeric antigen receptor (CAR) T cell therapies have advanced rapidly in recent years, with a number of targets in clinical research and several US Food and Drug Administration (FDA)-approved products already on the market. There has been tremendous effort to make CAR T cells more effective, safe, and persistent when treating patients. On the manufacturing side, however, errors, lot-to-lot variation, and contamination can be associated with open processes and manual handling of CAR T cells.
Cell isolation, gene editing, expansion, and cryopreservation are complex steps in a typical autologous CAR T cell manufacturing process. Integrating this complicated multistep workflow into a closed, modular, benchtop system can facilitate transitions from laboratory scale to clinical manufacturing and improve a CAR T cell product’s consistency, purity, and safety. Thermo Fisher Scientific presents a digitally compatible, good manufacturing practice (GMP)-compliant, semiautomated manufacturing platform, which when used with Gibco™ CTS™ reagents, protocols, and analytics can result in consistent, efficacious CAR T cell production.
![19-7-8-ThermoCellTher-F1-1024x448.jpg 19-7-8-ThermoCellTher-F1-1024x448.jpg](https://eu-images.contentstack.com/v3/assets/blt0a48a1f3edca9eb0/blt446363b07977dc59/658c0433282662040aa0579a/19-7-8-ThermoCellTher-F1-1024x448.jpg?width=700&auto=webp&quality=80&disable=upscale)
Figure 1: (top) CAR T cell therapy workflow; (bottom) workflow solutions from Thermo Fisher Scientific
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