Design of a New Range of High Capacity and High Flow Agarose Resins

With the continuing development of high titer cell lines, resins with very high capacity at relevant residence times are becoming increasingly important.
This paper will present application and characterization data from a set of novel, agarose-based resins, with ion exchange functionality as well as with immobilized alkaline stable Protein A.

The cation exchanger has a dynamic binding capacity of more than 120 mg monoclonal antibody/mL resin without the introduction of surface extenders. Performance data from an alkaline stable Protein A resin with a dynamic binding capacity of over 50 mg/mL will also be shown.