Challenges of Scale Up and Development of Insect Cell Culture and BEVS

This webcast features: Sharyn Farnsworth, Associate Principal Scientist, FUJIFILM Diosynth Biotechnologies

A strategy for scale up and implementation of Insect Cell Culture (ICC) should be assessed at the earliest stages of process development as there are a different set of challenges in the culture of ICC and BEVS versus a CHO culture and a limited number of vendors experienced enough to guide you through the adventure of manufacturing ICC. Each system has a unique problem set ranging from which cell line to use, where and how to bank the cells to what media to use to the strategy for viral preparation. Keeping track of where you want to end up can help shape the process and determine at what stage you want to implement the steps to make the process more reliable and robust as a manufactured product and not just something that is executed on the bench top.