Webinars

Effective Strategies for Endotoxin Removal in Therapeutic Protein Purification

This webcast features: Heidi Jones, MBA, Market Development Manager, Chromatography Applications & Collaborations,  Bio-Rad Laboratories. Endotoxins are common pyrogenic impurities in therapeutic protein preparations that make the next steps in the purification process very difficult. They are negatively charged complex aggregates of lipopolysaccharides released in large amounts from the outer membrane of gram-negative bacteria during mechanical cell lysis and death. Their presence in even minute concentrations in therapeutic protein preparations can cause septic shock, tissue injury, and even death. In…

An Essential PAT Technology for Downstream Processing in AAV Manufacturing

This webcast features: Racha Majed, PhD, Technical Sales Specialist, Refeyn & Quentin Bazot, PhD, Head of Innovation and Process Development, ABL, an Institut Mérieux Company. While gene therapies relying on adeno-associated virus (AAV) vectors are in high demand, so are the analytical methods that can constitute a robust process analytical technologies (PAT) toolbox. To ensure the production of high-quality AAV products, it is crucial to reliably and rapidly characterize samples based on critical quality attributes (CQAs) such as sample purity.…

Turning Biologic Innovation Into Commercial Success: Boehringer Ingelheim’s Expertise in Microbial Technology

This webcast features: Athelney Woolnough, Director Business Development/Key Account Management BioXcellence, Franz Schuster, Strategy Implementation Manager Biopharma Austria, Nikolaus Hammerschmidt, PhD, Head of Unit Downstream Development , Process Science, RCV, Boehringer Ingelheim. Boehringer Ingelheim BioXcellence™ offers comprehensive support for successful development and manufacturing, treating customers’ products as if they were their own. Their expertise spans both mammalian cell culture and microbial fermentation technologies. The microbial product landscape, a specialty market, demands a variety of manufacturing process formats to cater to different…

Tulip Tank Case Study: The Unrecognized Role of Mixing During TFF

This webcast features: Lucas Smith, Commercial Project Manager, TFF Systems, Repligen. The degree of homogeneity in the feed that is delivered to the filters is a critical, but often overlooked factor. Even small changes in the nature of the feed will drastically impact performance, resulting in deviations during diafiltration. This case study explores the impact of mixing dynamics on TFF performance. An innovative single-use Tulip Tank paired with the KrosFlo® RS 30 TFF system significantly improved performance as compared to…

Advanced Technology for Vector-Based Therapies Highlighting Stem Cell-Derived Exosomes Manufacturing Process

This webcast features: Elie Zakhem, PhD, PMP, Senior Manager, Process Development, RoosterBio Inc., Lauren Torres, Field Applications Scientist, Repligen, Jeremy Neidert, Bioprocessing Account Manager, Repligen. The number of clinical trials investigating viral vectors and MSC-EVs as therapeutic and skincare agents has been increasing greatly over the years. The complexity and fragility of the vector-based products, scalability, yield, and purity of production processes are challenges to meeting demand. With this comes the requirement to ensure that there are robust manufacturing processes…

Unmatched Productivity and Seamless Scalability: Advantages of the XCell® ATF System for Upstream Process Intensification

This webcast features: Muhammad Shamim, Field Applications Scientist, Upstream, Repligen. With the constant pressure of meeting aggressive process development timelines while continuously improving upstream cell culture yield and productivity, developing the optimal processes from the beginning is crucial. With over 500 adoptions at process and commercial scale across biopharma globally, the XCell® ATF System is a proven technology for intensified cell culture that exponentially boosts productivity, lowers costs, and expands capacity of existing manufacturing facilities in upstream bioprocessing. In this…

Innovation in Tangential Flow Filtration: Holder-Less Self-Contained Flat Sheet Cassette Device

This webcast features: Mark A. Perreault, Director, Research and Development, Repligen Tangential Flow Filtration (TFF) has been a cornerstone technology in bioprocessing, enabling the separation and concentration of biomolecules with precision and efficiency. In this study, we introduce a groundbreaking innovation in TFF technology with the launch of the first holder-less self-contained true flat sheet cassette device. This device represents a paradigm shift in TFF, eliminating the need for traditional cassettes holders while delivering performance comparable to conventional formats. In…

Development of Advanced Feed Media and Supplements for a Robust, Cost-Effective, and High-Productivity Process

This webcast features: Yaron Silberberg, PhD, Chief Scientist, Ajinomoto CELLiST Korea Co., Inc. Cell culture media composition and upstream bioprocess conditions are crucial factors affecting protein yield in the production of biologics and biosimilars. Recently, advanced new techniques were developed that use IT approaches, including computer simulation of bioprocesses, AI tools, and ‘multiomics’ methods for analysis of cellular metabolic pathways. These techniques allow optimization of both process and media composition for maximizing culture performance and protein production. In this webcast,…

Expansion of Samsung Biologics’ Business Into Late Discovery/Early Development

This webcast features: Derrick Katayama, Lead Scientist, Formulation Development, Samsung Biologics. As the global biopharmaceutical market rapidly expands, the increasing demand for drug development underscores the significance of effective assessment tools for selecting biologic compounds with adequate stability and developability. In response to these critical requirements, Samsung Biologics offers cutting-edge technology and an innovative approach from the early development stages with its advanced development platform, resulting in streamlined development time and costs. In this webinar, Samsung Biologics explores its proprietary…

CHT Chromatography Media: 5 Essential Facts

This webcast features: William H. Rushton, MS, Process Chromatography Support Scientist, Bio-Rad Laboratories. For over 30 years, CHT™ Ceramic Hydroxyapatite Chromatography Media has been a trusted, proven purification solution for many biopharmaceutical manufacturing processes. CHT provides exceptional removal of impurities when other chromatography resins fall short to provide the same level of purity. In this webcast, explore the essential facts and benefits of this chromatography technology. The 5 Essential Facts: CHT is eco-friendly and can help achieve your sustainability goals. CHT…