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Innovation in Tangential Flow Filtration: Holder-Less Self-Contained Flat Sheet Cassette Device
BPI Contributor
December 1, 2023
20 Min View
Date: Dec 1, 2023
Duration: 20 Min
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Sponsored by Repligen
This webcast features: Mark A. Perreault, Director, Research and Development, Repligen
Tangential Flow Filtration (TFF) has been a cornerstone technology in bioprocessing, enabling the separation and concentration of biomolecules with precision and efficiency. In this study, we introduce a groundbreaking innovation in TFF technology with the launch of the first holder-less self-contained true flat sheet cassette device. This device represents a paradigm shift in TFF, eliminating the need for traditional cassettes holders while delivering performance comparable to conventional formats. In this webinar, Repligen presents the TangenX SC Device, discuss benefits of a holder-less TFF process, and demonstrate comparability to traditional TFF cassettes while processing a crude monoclonal antibody (MAb) feed.
The introduction of the holder-less self-contained true flat sheet TFF device represents a significant advancement in TFF technology. Its versatility across bioprocessing applications and 80% reduction in process set up time opens new possibilities for simplifying and optimizing biomolecule manufacturing processes while maintaining product quality and yield.
Key Takeaways:
The novel TFF device introduces a holder-less design, simplifying the setup and reducing the risk of cassette installation issues, thereby improving process efficiency and reliability.
Easily scale from other cassette formats because the same channel path length is maintained across cassette formats with the same pressure drop profile from feed to retentate.
The device incorporates a true flat sheet cassette design, ensuring uniform flow distribution across the membrane surface, resulting in consistent performance and enhanced product recovery.
Testing reveals that the holder-less device delivers comparable performance to traditional cassette formats, achieving equivalent separation efficiency, flux rates, and fouling resistance.
To validate the device’s capabilities, we demonstrate its performance using both bovine IgG and a crude mAb feed stream. The device consistently achieves comparable recovery while effectively concentrating and diafiltering, demonstrating its suitability for critical bioprocessing applications.
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