Upstream

Aggressive Microbial Production from Inoculation Through Harvest in Single-Use Systems

This webcast features: Dmitrij Bugajev, R&D Scientist, and Jason D. Brown, Design Engineer, Thermo Fisher Scientific Single-use fermentors enable production facilities to utilize single-use technologies instead of traditional stainless-steel fermentor vessels, achieving equivalent expression with rapidly growing high-density cultures. In this webcast, we will compare some results from various processes with yeast and bacteria before and after technology transferred to single-use at our two facilities. We will give you our feedback as previous end users of stainless-steel fermentors and now…

CHOgro® High Yield Expression System: Achieve Higher Titers Faster in Suspension CHO Cells

This webcast features: Leisha Kopp, Applications Scientist, Mirus Bio Suspension Chinese Hamster Ovary (CHO) cells are often utilized for protein expression in biomanufacturing given their capacity for high-density growth in chemically defined media, human-biosimilar posttranslational modifications, and strong history of regulatory approval by the US Food and Drug Administration (FDA). However, many early stage researchers rely on HEK 293 systems for screening candidate compounds because of additional costs and time associated with production in CHO cells. The CHOgro® High Yield…

Single-Use Technologies: Innovation and Performance

The biotherapeutic market has been rapidly adopting single-use technologies to reduce risk and improve operational efficiencies. For more than 20 years, Thermo Fisher Scientific has pioneered single-use technologies for this industry. Our products have been proven to be robust and scalable from laboratory scale-up to current good manufacturing practice (cGMP) production applications, including single-use bioprocessing equipment, flexible containment, and rigid containment product portfolios. Our webinars will explore data, innovative products, and novel strategies featuring single-use solutions for the bioprocessing market.…

Robust Stable Line Platform for Biologics Development

This webcast features: Dr. Sean Liour, Vice President for Project Management, GenScript ProBio A cell line platform can provide the best solution for the biopharmaceutical target. This webinar explains how to develop a robust stable line platform for CMC projects. GenScript’s biologics platform can provide one-stop service of CMC for the biopharmaceutical target. Just fill out the form below to watch the recorded webcast now.

Accelerating Timelines by Integrating Cell Line Development and Manufacturing Programs

This webcast features: Nicole Wakes, Group Leader, Cell Line Development, Abzena The start of cell line development represents a significant milestone for biologics innovators: It’s a commitment to a specific molecule and the start of the journey towards IND. By using the latest technologies such as automated multiple microscale bioreactors and high-throughput analytics, it is possible to interrogate clones more closely to determine productivity, manufacturability, and performance at scale and at an early stage. In addition, the data generated can…

Implementation of Single-Use Fermentation Technology

This webcast features: Andrew Lowell, Associate Director, Upstream Process Development, KBI Biopharma, Inc. KBI Biopharma, Inc. has implemented single-use fermentation (SUF) systems that have allowed greater throughput and efficiency in the laboratory, leading to accelerated project timelines to good manufacturing practice (GMP) production. The single-use fermentation systems address those programs with relatively small material needs while decreasing validation requirements and increasing operational efficiencies. Coupling process design with the SUF equipment capabilities has enabled processes capable of high cell densities and…

Using Slope Spectroscopy for Faster, Repeatable, More Accurate Protein Concentration Measurements

This webcast features: Joe Ferraiolo, Bioanalytics Applications Manager, Repligen Traditional capture chromatography titer measurements that involve dilution requirements represent the highest single source of error in traditional UV analysis. Slope spectroscopy requires no sample preparation or dilution, saving substantial time without changing any other aspects of the assay. This webinar will demonstrate how variable pathlength slope spectroscopy using the SoloVPE™ device can significantly reduce sample prep and process time, while maintaining high repeatability and accuracy. Just fill out the form…

Cell Culture Media Analysis Using a Handheld Raman Analyzer with Onboard Chemometrics

This webcast features: Orville Dean Stuart, Technical Regional Sales Manager, Thermo Fisher Scientific This webinar presents the use of a handheld Raman analyzer with onboard chemometrics to verify the identify and monitor the quality and batch-to-batch variability of both dry powder chemically defined media and ready-to use liquid cell culture media. While scans of cell culture media using Thermo Scientific’s TruScan RM handheld Raman analyzer produce spectra with good Raman features, due to similar constituents and formulations, the TruTools add-on…

MYCAP CCX flask cap

Transform Cell Expansion: Expand Outside the Hood

This webcast features: Charles Meadows, Head of Product Management, Smart Consumables, Sartorius-Stedim Biotech Cell Culture expansion from vial to seed bioreactor is done by passaging culture through successively larger Erlenmeyer shake flasks. Sampling, media feed, inoculation and transfers are done non-aseptically by unscrewing the cap in a biosafety cabinet (BSC). Contaminated expansions due to non-aseptic technique are abandoned costing time and materials. Sartorius leveraged novel bottle closure manufacturing technology to create MYCAP® CCX. MYCAP® CCX combines tubing for aseptic fluid…

ekko: How Acoustics Cell Processing is Changing Cell and Gene Manufacturing

This presentation features: Kevin Lannon, Director of Global Sales, FloDesign Sonics With an ever-increasing number of cell and gene therapies approaching commercialization, the industry is looking for scalable manufacturing solutions. In order to truly see a step change in improvement, it is crucial for tool providers to design equipment specifically for the GMP environment and the unique needs of cell and gene processing. This presentation will outline: How acoustophoresis and the ekko™ platform is changing the cell processing paradigm Overview…