Continuous Chromatography: A Multifunctional, Twin-Column Continuous Chromatography in a Simple, Robust Design

LEWA EcoPrime® Twin LPLC is an easy-to-use, GMP-ready, multicolumn chromatography system offering analytical performance for continuous chromatography from process development to large-scale biopharmaceutical production. The EcoPrime Twin platform spans a wide range of flow and column sizes and has several options to incorporate multiple functionality on a single unit. The EcoPrime Twin system is built on ChromaCon’s Contichrom patented approach to twin-column purification. Because of the two-column configuration, the EcoPrime Twin system is a simple design that facilitates continuous chromatography implementation, reduces risk of costly downtime, and minimizes operating expenses. It is well suited for capture steps using protein A or ion-exchange (IEX) separations for monoclonal antibody, recombinant, or plasma protein purification processes.

One System, Multifunction
This advanced system can be configured to operate in multiple modes: batch and continuous chromatography with enhanced buffer in line dilution (BID). The design accommodates parallel or in-series column configurations for integrated batches using an on-board BID for in-line buffer preparation and conditioning, thus eliminating any hold-up step.

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