Enabling High-Performing Perfusion Cell Culture

Figure 1: Viable cell volume (VCV) and viability data for HIP CHO in the HyPerforma 3-L Glass Bioreactor and 50-L DynaDrive Single-Use Bioreactor cell runs

At least one report estimates that by 2025, 35% of biologics will be manufactured using enhanced processes, particularly perfusion-based bioprocessing. Results of two innovations that support this need for enhanced processes are examined below.

The Thermo Scientific HyPerforma DynaDrive Single-Use Bioreactor (SUB), the latest advancement in SUB technology, offers better performance than other bioreactors and scalability up to 5,000 L. Gibco High-Intensity Perfusion CHO Medium is formulated to provide exceptional performance and ease of use, with capability of sustaining >1 g/L/day continuous productivity, >100 x 10⁶/mL cell density, and 95% viability at one vessel volume per day (VVD).

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