June 20, 2019
Date: Jun 20, 2019
Duration: 20 Min
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This webcast is no longer available.
This webcast features: Stephen Tottey, PhD, Associate Principal Scientist, Process and Technology Development, Wuxi Advanced Therapies and John Taylor, Process Development Scientist, MilliporeSigma.
Clarification of non-settled Lenti suspension harvest can be challenging due to high level of impurities in the feed stream, physical characteristics of the vector, limited filter choices, and low recovery. A series of clarification studies led to the identification of two feasible clarification filter set up options that provide workable outcomes regarding product recovery, impurity reduction, process throughput and scalability.
Key Lessons Learned:
Solution for clarification of non-settled Lenti suspension harvest challenges.
Two workable clarification filter set up options were developed.
It is feasible to clarify non-settled suspension harvest at 1000L scale or larger.
This webcast is no longer available.
The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.
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