Monoclonal Antibody Production - Viral Clearance and Host-Cell Protein Reduction Using a High-Capacity, Single-Use, Strong Anion-Exchange Device

Strong anion-exchange (Q) chromatography is an industry standard for polishing purification steps of monoclonal antibody (MAb) production. It is a proven technology that removes viruses and host-cell proteins (HCP) from process feed streams in flow-through mode. NatriFlo HD-Q device adsorbers feature a hydrogel membrane, which combines high dynamic binding capacity and salt tolerance to deliver best-in-class performance. This makes it possible to rapidly process-large sample volumes using a small disposable device. This article examines the ability of NatriFlo HD-Q adsorbers to clear virus and HCP from partially purified (post–protein A) MAb solutions.

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