Vaccine Downstream Production: Purification Tools for Various Modalities

As vaccine modalities abound, this special report provides a consolidated overview of a variety of chromatographic purification tools for various vaccine modalities, such as virus-like particles (VLPs), viral vectors, recombinant protein subunits, and mRNA-based vaccines. This includes a successful protein-based malaria vaccine production process highlighting the use of the C-tag affinity tag system as a versatile tool for the detection and purification of therapeutic recombinant proteins. Next, it explores the scalable purification of mRNA-based vaccines, such as those deployed against COVID-19, with the application of POROS(TM) Oligo(dT)25 affinity resin. Further, cation exchange chromatography tools are highlighted by the purification of VLPs against human papillomavirus (HPV) using POROS(TM) HS50 resin. Additionally, the baculovirus expression vector system (BEVS) for insect-cell expression of recombinant proteins is presented, with a focus on VLP manufacturing and purification tools, showcasing the capabilities of these technologies in advancing vaccine development and production.

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