Wednesday, December 22, 2021 Daily Archives

Chromatography in mRNA Production Workflow

Rapid response to global pandemics requires the manufacture of billions of vaccine doses within months. This short timeline must allow for design and testing of active ingredients, development of production and purification processes, clinical evaluations, regulatory filings, and manufacturing. Existing purification methods often have been adopted from laboratory-scale techniques to allow rapid implementation, and those have provided adequate product quality. But future mRNA development will require optimized production and purification processes. Chromatography has been a workhorse of biomanufacturing for decades,…

WHP Engineering: The key things to consider when planning a facility

Ian Lichfield, CEO of WHP Engineering figuratively sat down with BioProcess Insider to discuss the key things to consider when planning a facility and how the business will adapt to suspected future changes. WHP Engineering is located in Newcastle, UK and describes itself on LinkedIn as a “multi-disciplined, engineering company dedicated to providing both standalone and turnkey solutions for highly-regulated, controlled environments and complex manufacturing processes across Europe.” The firm works with a wide range of customers in the life…

RNA sector set for progress thanks to decades long research drive

The RNA drug sector has overcome some significant hurdles according to Alynlam Therapeutics CEO John Maraganore, who says industry efforts to work with these challenging molecules have laid the foundations for growth. “The scientific obstacles are best defined here, small interfering RNA molecules are large. They’re charged. They’re susceptible to biological degradation. They’re also prone to activated immune sensor systems. And so the challenge of making drugs out of small interfering RNAs was really a formidable scientific challenge that needed…